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MC4R=melanocortin-4 receptor.
Rhythm InTune is a support program dedicated to providing resources, education, and information tailored to fit the unique needs of people living with certain rare genetic diseases of obesity, including BBS. To be contacted by a Patient Education Manager for personalized support, please fill out a Patient Consent Form.
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IMCIVREE is a prescription medicine used in adults and children 6 years of age and older with obesity due to Bardet-Biedl syndrome (BBS) to help them lose weight and keep the weight off.
IMCIVREE is not for use in people with the following conditions because it may not work:
It is not known if IMCIVREE is safe and effective in children under 6 years of age.
IMCIVREE reduced BMI Z-scores in children over the course of the 1-year clinical trial
IMCIVREE showed early, significant, and continued weight reduction in adults
Average reductions in weight over the course of the 1-year clinical trial:
In the clinical trial, people were not required to change their diet or exercise routine.
IMCIVREE reduced the most severe feelings of hunger in the clinical trial
What are the possible side effects of IMCIVREE?
*IMCIVREE was studied in both children and adults in a 66-week clinical trial. The trial was the largest ever to assess weight and hunger reduction in people living with BBS. 31 people, 6 years of age and older, with obesity and a clinical diagnosis of BBS were evaluated. Adults in the trial had to have a BMI of 30 or more, and children had to have a weight in the 97th percentile or higher.
†N=14. N is the number of people evaluated. A clinically meaningful reduction is generally defined as a reduction of greater than or equal to 0.2 in BMI Z-score.
‡N=12.
§Hyperpigmentation.
Before you use IMCIVREE, tell your healthcare provider about all your medical conditions, including if you:
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements.
See the detailed Instructions for Use that come with your IMCIVREE to learn how to prepare and inject IMCIVREE, and how to properly throw away (dispose of) used syringes and needles.
What are the possible side effects of IMCIVREE?
IMCIVREE may cause serious side effects, including:
The most common side effects of IMCIVREE include darkening of the skin, injection site reactions, nausea, headache, diarrhea, stomach pain, vomiting, depression, and an erection that happens without any sexual activity in males.
These are not all the possible side effects of IMCIVREE. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or to Rhythm Pharmaceuticals at 1-833-789-6337.
If you're a US resident who wants to receive updates about IMCIVREE, please complete the form below.
All fields required unless otherwise noted.
Before you use IMCIVREE, tell your healthcare provider about all your medical conditions, including if you:
What is IMCIVREE?
IMCIVREE is a prescription medicine used in adults and children 6 years of age and older with obesity due to: